DNA-PKcs inhibitor KU-57788 synergizes with ferroptosis in anaplastic thyroid cancer cells
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Thyroid cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × KU_24H vs 3 × KU_48H vs 3 × CON_24H vs 3 × CON_48HGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Direct coupling and protective activation of DRP1 by the DNA-PKcs inhibitor KU-57788 synergizes with ferroptosis in anaplastic thyroid cancer cellsCell death & disease · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319513_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1423652 and SRA study SRP677058. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9518960 KU_24H1 KU_24H
- GSM9518961 KU_24H2 KU_24H
- GSM9518962 KU_24H3 KU_24H
- GSM9518963 KU_48H1 KU_48H
- GSM9518964 KU_48H2 KU_48H
- GSM9518965 KU_48H3 KU_48H
- GSM9518966 CON_24H1 CON_24H
- GSM9518967 CON_24H2 CON_24H
- GSM9518968 CON_24H3 CON_24H
- GSM9518969 CON_48H1 CON_48H
- GSM9518970 CON_48H2 CON_48H
- GSM9518971 CON_48H3 CON_48H
- GSE327924 CRISPR-Based Gene Dependency Screens reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer 16 samples same disease briefing · shares anaplastic, inhibitor, thyroid
- GSE299493 Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma 6 samples same disease briefing · shares synergizes, anaplastic, thyroid
- GSE193581 Anaplastic Transformation Model in Thyroid Cancer Revealed by Single Cell Lineage and Fate Analysis 32 samples same disease briefing · shares anaplastic, thyroid
- GSE284824 CRISPR/Cas9-mediated deletion of MADD induces cell cycle arrest and apoptosis in anaplastic thyroid cancer cells 18 samples same disease briefing · shares anaplastic, thyroid
- GSE266999 Auranofin as a novel anticancer drug for anaplastic thyroid cancer 8 samples same disease briefing · shares anaplastic, thyroid
- GSE272374 Maintenance of magnesium homeostasis by NUF2 promotes protein synthesis and anaplastic thyroid cancer progression 6 samples same disease briefing · shares anaplastic, thyroid
- GSE291054 POLR1F promotes proliferation and stemness of anaplastic thyroid cancer by activating F2R/p38 MAPK signaling 6 samples same disease briefing · shares anaplastic, thyroid
- GSE235216 Single cell RNA sequencing of In vivo mouse xenograft tissues from two human TRa1 anaplastic thyroid cancer cell line 4 samples same disease briefing · shares anaplastic, thyroid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.