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Combination with oxaliplatin improves abscopal effect of oncolytic virotherapy through reorganization of intratumoral macrophages [scRNA-seq]

GSE299510 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/01 Platform GPL30172
Summary
Oncolytic virotherapy is a unique and promising immunotherapy. In our prior study, a recombinant oncolytic vaccinia virus carrying IL-7 and IL-12 (hIL-7/mIL-12-VV) showed robust antitumor efficacy in both immunogenic CT26.WT and poorly immunogenic Lewis lung carcinoma (LLC) within the treated tumors. However, the efficacy was limited in virus non-treated (distant) LLC tumors. Here we identified oxaliplatin as a powerful combination partner for an oncolytic vaccinia virus to achieve strong efficacy in the virus-injected tumors and the distant tumors. To understand the molecular and cellular mechanisms underlying the improved abscopal effect of the combination treatment, distant LLC tumors were assessed via single cell RNA-sequencing.
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Direct links to NCBI, no account and no request form: the whole study as GSE299510_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1274874 and SRA study SRP591486. Searching any of these in the dataset finder brings you back here.

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