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Methionine metabolism regulates T cell fate by KCa3.1 activity (RNA-Seq)

GSE299554 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/06/11 Platform GPL24247
Summary
We found that methionine availibility during T cell activation regulates rapid NFAT1 activation, thereby governing T cell fate. Further, acute methionine limitation didn't affect global histone methylation status stating the crucial role of methioinine during early TCR activation.
Published in
Early methionine availability attenuates T cell exhaustion
Sharma P, Guo A, Poudel S et al. · Nature immunology 2025 · PMID 40702340 · doi:10.1038/s41590-025-02223-6
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Also filed as BioProject PRJNA1274971 and SRA study SRP591390. Searching any of these in the dataset finder brings you back here.

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