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Fundamental mechanisms causing pituitary stem cell aging in mice and humans

GSE299835 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/06/27 Platform GPL34328
Summary
The pituitary gland produces hormones that are required to maintain proper endocrine function throughout adult life, but organ function declines with age. In particular, pituitary stem cells lose their ability to regenerate hormone-producing cells in response to organ damage by middle age in mice. In this proposal, we will use cutting edge single-cell RNA sequencing and human induced pluripotent stem cell techniques to determine genes responsible for pituitary stem cell aging in hopes of prolonging the window of regeneration in vivo.
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Direct links to NCBI, no account and no request form: the whole study as GSE299835_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1276598 and SRA study SRP592015. Searching any of these in the dataset finder brings you back here.

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