Transcriptional changes in response to TGFB in human pancreatic stellate cells with inhibition of PIN1
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic CancerCancer research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299851_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1277145 and SRA study SRP592403. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9047753 hPSC, DMSO, untreated, rep1 hPSC, DMSO, untreated,
- GSM9047754 hPSC, DMSO, TGFB, rep1 hPSC, DMSO, TGFB,
- GSM9047755 hPSC, KPT, untreated, rep1 hPSC, KPT, untreated,
- GSM9047756 hPSC, KPT, TGFB, rep1 hPSC, KPT, TGFB,
- GSM9047757 hPSC, ATRA, untreated, rep1 hPSC, ATRA, untreated,
- GSM9047758 hPSC, ATRA, TGFB, rep1 hPSC, ATRA, TGFB,
- GSM9047759 hPSC, DMSO, untreated, rep2 hPSC, DMSO, untreated,
- GSM9047760 hPSC, DMSO, TGFB, rep2 hPSC, DMSO, TGFB,
- GSM9047761 hPSC, KPT, untreated, rep2 hPSC, KPT, untreated,
- GSM9047762 hPSC, KPT, TGFB, rep2 hPSC, KPT, TGFB,
- GSM9047763 hPSC, ATRA, untreated, rep2 hPSC, ATRA, untreated,
- GSM9047764 hPSC, ATRA, TGFB, rep2 hPSC, ATRA, TGFB,
- GSM9047765 hPSC, DMSO, untreated, rep3 hPSC, DMSO, untreated,
- GSM9047766 hPSC, DMSO, TGFB, rep3 hPSC, DMSO, TGFB,
- GSM9047767 hPSC, KPT, untreated, rep3 hPSC, KPT, untreated,
- GSM9047768 hPSC, KPT, TGFB, rep3 hPSC, KPT, TGFB,
- GSM9047769 hPSC, ATRA, untreated, rep3 hPSC, ATRA, untreated,
- GSM9047770 hPSC, ATRA, TGFB, rep3 hPSC, ATRA, TGFB,
- GSE253493 RNA-Seq experiment of primary hepatic stellate cells (HSCs) and LX-2 cell line treated with TGFb 12 samples shares tgfb, stellate
- GSE263733 Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications 218 samples shares pancreatic, changes
- GSE310675 CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer 12 samples shares pancreatic, inhibition
- GSE312205 Splicing inhibition hampers pancreatic cancer cell viability by disrupting DNA repair proficiency and mitotic checkpoint integrity 12 samples shares pancreatic, inhibition
- GSE244396 Binding Changes in Chromatin Factors Upon Targeted XPO1 Inhibition in T Cells 20 samples shares inhibition, changes
- GSE335339 PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension [BID-seq] 20 samples shares tgfb
- GSE143584 Gene expression from laser capture microdissected epithelium and stroma during pancreatic carcinogenesis 366 samples shares pancreatic
- GSE298581 Global gene expression response to PPARG inhibition in three urothelial cancer cell lines 48 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.