N-acetyl-L-cysteine ethyl ester (NACET) induces the transcription factor NRF2 in the retina and prevents its aging and diabetic retinopathy. [III]
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 16 × male vs 4 × femaleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- N-acetyl-l-cysteine ethyl ester (NACET) induces the transcription factor NRF2 and prevents retinal aging and diabetic retinopathyRedox biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299877_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1277210 and SRA study SRP592402. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 2 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9048250 1) Young_Ctrl_rep1; age 119 days; sex:male male
- GSM9048251 2) Young_Ctrl_rep2; age 119 days; sex:male male
- GSM9048252 3) Young_Ctrl_rep3; age 119 days; sex:female female
- GSM9048253 4) Young_Ctrl_rep4; age 119 days; sex:female female
- GSM9048254 5) Young_NACET_rep1; age 129 days; sex:male male
- GSM9048255 6) Young_NACET_rep2; age 129 days; sex:male male
- GSM9048256 7) Young_NACET_rep3; age 129 days; sex:male male
- GSM9048257 8) Young_NACET_rep4; age 129 days; sex:male male
- GSM9048258 9) Young_NACET_rep5; age 119 days; sex:female female
- GSM9048259 10) Young_NACET_rep6; age 119 days; sex:female female
- GSM9048260 11) Old_Ctrl_rep1; age 668 days; sex:male male
- GSM9048261 12) Old_Ctrl_rep2; age 668 days; sex:male male
- GSM9048262 13) Old_Ctrl_rep3; age 668 days; sex:male male
- GSM9048263 14) Old_Ctrl_rep4; age 668 days; sex:male male
- GSM9048264 15) Old_NACET_rep1; age 668 days; sex:male male
- GSM9048265 16) Old_NACET_rep2; age 668 days; sex:male male
- GSM9048266 17) Old_NACET_rep3; age 581 days; sex:male male
- GSM9048267 18) Old_NACET_rep4; age 581 days; sex:male male
- GSM9048268 19) Old_NACET_rep5; age 574 days; sex:male male
- GSM9048269 20) Old_NACET_rep6; age 574 days; sex:male male
- GSE299879 N-acetyl-L-cysteine ethyl ester (NACET) induces the transcription factor NRF2 in the retina and prevents its aging and diabetic retinopathy. [IV] 18 samples shares nacet, nrf2, n-acetyl-l-cysteine, transcription, retinopathy, prevents, diabetic
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- GSE291182 MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut III 7 samples shares iii, prevents
- GSE282678 Dynamic regulation of murine RNA Polymerase III transcription during heat shock stress 28 samples shares iii, transcription
- GSE224756 Redox sensor KEAP1 promotes stemness and prevents reductive stress in exhausted CD8+ T cells via inhibiting NRF2 18 samples shares nrf2, prevents
- GSE71263 Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription 12 samples shares nrf2, transcription
- GSE273535 Mechanical Loading remodels transcriptional regulation in Osteocytes through Nucleus translocation of NRF2 [ChIP-seq] 11 samples shares nrf2, transcription
- GSE296151 Identifying and Exploiting Combinatorial Synthetic Lethality by Characterizing Adaptive Kinome Rewiring of EGFRvIII-driven Glioblastoma 80 samples shares iii
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.