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FET-Rearranged Soft Tissue Myoepithelial Tumors Span a Broad Clinicopathologic and Molecular Spectrum that is Epigenetically Distinct from Cutaneous and Head and Neck Myoepithelial Tumors

GSE300102 Homo sapiens (human) DNA methylation 52 samples Submitted 2025/11/09 Platform GPL33022
At a glance

DNA methylation · human · 52 samples

What it is
DNA methylationChemical marks on DNA that help switch genes on or off.
Organism
Homo sapiens (human)
Samples
52 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI.
Summary (written by the submitters)
DNA methylation profiling from a multi-institutional cohort of 52 fusion-positive MET cases were analyzed. Pooled clinicopathological and outcome analysis with new and published cases (total 185 and 69 cases, respectively) was performed. The MET subgroups, EWSR1::KLF15, EWSR1/FUS::KLF17, EWSR1::PBX1, EWSR1::PBX3, EWSR1/FUS::POU5F1, SS18::POU5F1, and EWSR1::ZNF444, showed significant heterogeneity in age group, site, and histology.
Read the full summary ↓
DNA methylation analysis revealed that fusion-positive MET were epigenetically related to each other and EWSR1/FUS::NFATC2 sarcomas, but entirely distinct from the epigenetically-related PLAG1-rearranged and salivary gland MET.
This dataset
Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗
3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE300102_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.

Also filed as BioProject PRJNA1279029. Searching any of these in the dataset finder brings you back here.

Samples in this study

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