← BioTransfer GEO Dataset Finder
GEO series

Transcriptome profiling of parental and lenvatinib-resistant TPC-1 thyroid cancer cells

GSE300132 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/18 Platform GPL24676
Summary
To uncover transcriptional alterations associated with lenvatinib resistance in papillary thyroid carcinoma, we performed paired-end RNA-Seq (2 × 150 bp, NovaSeq 6000) on parental TPC-1 cells and an in-house generated lenvatinib-resistant sub-line (TPC-1-Len). Total RNA from three biological replicates per group was extracted with TRIzol, libraries were prepared with poly(A) selection, and sequencing was carried out at OE Biotech (Shanghai, China). Differential gene expression was analysed using DESeq2 (Q < 0.05)
Published in
The KRT15 and KRT81 complex promotes lenvatinib resistance in thyroid cancer by upregulating DGKB mediated lipid metabolism
Wang Y, Zhang Y, Zhao D et al. · Scientific reports 2026 · PMID 41991644 · doi:10.1038/s41598-026-47994-6
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE300132_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1279090 and SRA study SRP592927. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.