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Circulating CD34+ Fibroblast Progenitors Participate in Heart Fibrosis of Allografts in Humans and Mice

GSE300168 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/01/02 Platform GPL24247
Summary
In this study, we employed single-cell RNA sequencing (scRNA-seq; 10X Genomics platform) combined with genetic lineage tracing in mouse models to comprehensively characterize the non-cardiomyocyte cellular composition of cardiac allografts. Fibrosis is one of the major causes of cardiac allograft malfunction, and is mainly driven by fibroblasts. In this study, we proposed that recipiene derived cells, expecailly CD34+ populations, are an important source of allograft fibroblasts, and play a crucial role in the fibrosis of transplanted hearts.
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Direct links to NCBI, no account and no request form: the whole study as GSE300168_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1279166 and SRA study SRP592985. Searching any of these in the dataset finder brings you back here.

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