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RNA sequencing of Primary urothelial carcinoma (UC)

GSE300195 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/28 Platform GPL24676
Summary
HER2 is an oncogenic driver in multiple cancers and a predictive biomarker for HER2-targeted therapies. While HER2-directed therapies like fam-trastuzumab deruxtecan (T-DXd) are approved for HER2-positive breast and other solid tumors, the landscape of HER2 expression in advanced prostate cancer (PC) and urothelial carcinoma (UC) remains inadequately characterized.This study demonstrates that HER2 is rarely overexpressed in metastatic prostate cancer but is more common and consistent in urothelial carcinoma. These findings highlight the need for HER2 testing in urothelial cancer.
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Direct links to NCBI, no account and no request form: the whole study as GSE300195_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1279207 and SRA study SRP593000. Searching any of these in the dataset finder brings you back here.

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