CASZ1 regulates the rate at which outer hair cells mature and is required for hearing
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × orgCorti_Casz1-KO vs 5 × orgCorti_Casz1-WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CASZ1 regulates the rate at which outer hair cells mature and is required for hearingbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300215_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1279854 and SRA study SRP593282. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9055886 orgCorti_Casz1-KO_rep1 orgCorti_Casz1-KO
- GSM9055887 orgCorti_Casz1-KO_rep2 orgCorti_Casz1-KO
- GSM9055888 orgCorti_Casz1-KO_rep3 orgCorti_Casz1-KO
- GSM9055889 orgCorti_Casz1-KO_rep4 orgCorti_Casz1-KO
- GSM9055890 orgCorti_Casz1-KO_rep5 orgCorti_Casz1-KO
- GSM9055891 orgCorti_Casz1-WT_rep1 orgCorti_Casz1-WT
- GSM9055892 orgCorti_Casz1-WT_rep2 orgCorti_Casz1-WT
- GSM9055893 orgCorti_Casz1-WT_rep3 orgCorti_Casz1-WT
- GSM9055894 orgCorti_Casz1-WT_rep4 orgCorti_Casz1-WT
- GSM9055895 orgCorti_Casz1-WT_rep5 orgCorti_Casz1-WT
- GSE249055 Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival 73 samples shares casz1, required, outer, hair
- GSE246143 MYO7a is required for the functional integrity of the mechanoelectrical transduction complex in the outer hair cells of the adult cochlea. 14 samples shares required, outer, hair
- GSE248180 Maternal SMARCA5 is required for major ZGA in mouse [RNA-seq] 138 samples shares required
- GSE278534 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization 76 samples shares required
- GSE290602 UHRF1-Mediated Maintenance DNA Methylation is Required for Induced Regulatory T Cell Function Following Influenza Induced Lung Injury in Young Adult Mice [invitro RNA-seq] 58 samples shares required
- GSE297143 EZH2 alters aggressive variant prostate cancer subtype evolution, but is not required for neuroendocrine prostate cancer [RNAseq] 54 samples shares required
- GSE218858 Hyperactive STAT5 Hijacks T-Cell Receptor Signaling and Drives Immature T-Cell Acute Lymphoblastic Leukemia 51 samples shares mature
- GSE280514 Spatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair. 48 samples shares required
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.