GEO series
Macrophage-derived Chemokine (C-C motif) ligand 24 (CCL24) promotes cardiac fibrosis
GSE300219
Mus musculus
Expression profiling by high throughput sequencing
14 samples
2025/09/17
GPL34328
Summary
Cardiac resident macrophages (CRMs) have key roles in progression and prevention of cardiac fibrosis. We have previously shown CRMs are a genetically diverse and heterogenous cell population. Using single-cell RNA sequencing we identified a CRM subset with high expression of Chemokine (C-C motif) ligand 24 (CCL24). In this study, we uncover a profibrotic role for CCL24 through fibroblast activation and regulation of ECM pathways.
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