GEO series
TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells
GSE300358
Homo sapiens
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
40 samples
2026/02/04
GPL24676
Summary
During pre-malignant hyperplastic growth, TGFβ restricts cell proliferation and inflammation, while on the other hand, TGFβ promotes migration and distal metastasis of cancer cells. To dissect the temporal chromatin-based transcriptional response to TGFβ, we employed 3D culture models of isogenic human breast epithelial cells, exemplified by non-oncogenic MCF-10A (MI) and its HRAS-transformed counterpart (MII). Genome-wide chromatin accessibility profiling revealed the extensive chromatin opening induced by TGFβ at transcription start sites and enhancer elements in both models, with a marked enrichment of SOX4 binding motifs in oncogenic cells.
Download
NCBI GEO page ↗
Paper (PMID 41639049) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE300595 Multiomic sequencing identifies myeloid cell associations with neoadjuvant chemotherapy treatment response in pancreatic adenocarcinoma (PDAC) 24 samples
- GSE335464 Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals [single cell] 28 samples
- GSE307120 Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma 21 samples
- GSE263717 Epigenomic profiles of SLE resting and transitional B cells 150 samples
- GSE241581 DCAF15 control of cohesin dynamics sustains acute myeloid leukemia 36 samples
- GSE233321 Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures 118 samples
- GSE283005 Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a neurons 60 samples
- GSE342612 Transcriptomic and H3K27ac chromatin responses of human microglia to acute PFOS exposure and recovery 36 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.