GEO series
Motor learning drives region-specific transcriptomic remodeling in the motor cortex and dorsal striatum
GSE300408
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2026/03/10
GPL21103
Summary
Motor learning depends on coordinated activity across the motor cortex (M1) and dorsal striatum (dSTR), yet the molecular mechanisms driving learning-related synaptic and circuit remodeling remain unclear. Here, we combine activity-dependent genetic labeling (TRAP) with single-cell RNA sequencing to generate an unbiased, cell type-resolved transcriptional atlas of behaviorally engaged populations during a forelimb reaching task.
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Paper (PMID 40791319) ↗
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