TET3 Promotes Tumor Immune Evasion Through Negative Regulation of Type I Interferon Signaling [RNA-Seq]
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300460_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1281004 and SRA study SRP594078. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9060863 MCF7_WT_mRNAseq_rep1 MCF7_WT_mRNAseq
- GSM9060864 MCF7_WT_mRNAseq_rep2 MCF7_WT_mRNAseq
- GSM9060865 MCF7_TET3KO_mRNAseq_rep1 MCF7_TET3KO_mRNAseq
- GSM9060866 MCF7_TET3KO_mRNAseq_rep2 MCF7_TET3KO_mRNAseq
- GSM9060867 MCF7_shscramble_mRNAseq_rep1 MCF7_shscramble_mRNAseq
- GSM9060868 MCF7_shscramble_mRNAseq_rep2 MCF7_shscramble_mRNAseq
- GSM9060869 MCF7_shTET3-1_mRNAseq_rep1 MCF7_shTET3-1_mRNAseq
- GSM9060870 MCF7_shTET3-1_mRNAseq_rep2 MCF7_shTET3-1_mRNAseq
- GSM9060871 MCF7_shTET3-2_mRNAseq_rep1 MCF7_shTET3-2_mRNAseq
- GSM9060872 MCF7_shTET3-2_mRNAseq_rep2 MCF7_shTET3-2_mRNAseq
- GSM9060873 B16F10_WT_mRNAseq_rep1 B16F10_WT_mRNAseq
- GSM9060874 B16F10_WT_mRNAseq_rep2 B16F10_WT_mRNAseq
- GSM9060875 B16F10_Tet3KO_mRNAseq_rep1 B16F10_Tet3KO_mRNAseq
- GSM9060877 B16F10_Tet3KO_mRNAseq_rep2 B16F10_Tet3KO_mRNAseq
- GSM9060878 B16F10_siNC_RiboZero_rep1 B16F10_siNC_RiboZero
- GSM9060880 B16F10_siNC_RiboZero_rep2 B16F10_siNC_RiboZero
- GSM9060882 B16F10_siTet3-1_RiboZero_rep1 B16F10_siTet3-1_RiboZero
- GSM9060884 B16F10_siTet3-1_RiboZero_rep2 B16F10_siTet3-1_RiboZero
- GSM9060886 B16F10_siTet3-2_RiboZero_rep1 B16F10_siTet3-2_RiboZero
- GSM9060889 B16F10_siTet3-2_RiboZero_rep2 B16F10_siTet3-2_RiboZero
- GSE300464 TET3 Promotes Tumor Immune Evasion Through Negative Regulation of Type I Interferon Signaling 28 samples shares tet3, interferon, promotes, negative, evasion, type
- GSE270550 Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation [RNA-Seq] 75 samples shares promotes, rna-seq
- GSE269054 Spatially clustered type I interferon responses at injury borderzones 37 samples shares interferon, type
- GSE247936 YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies 46 samples shares promotes, evasion
- GSE241209 Tissue factor binds to and inhibits interferon-α receptor-1 signaling 21 samples shares interferon
- GSE296402 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity 66 samples shares promotes
- GSE253518 Interferon epsilon as a novel anti-viral agent in the testis 61 samples shares interferon
- GSE293117 GPR34 loss-of-function rescues TREM2 metabolic dysfunction and promotes responsive microglial states 56 samples shares promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.