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scRNAseq analysis of lung treated with GLS1 inhibitor [scRNA-seq Lung_BPTES]

GSE300532 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/02 Platform GPL28457
Summary
We employed the Chromium GEM-X single-cell RNA sequencing platform by 10x Genomics to investigate the effects of the GLS1 inhibitor, BPTES, on the lung single-cell transcriptome of 19- to 20-month-old wild-type male mice. Previous studies have identified GLS1 as a potential senolytic reagent capable of eliminating senescent cells. Our aim was to determine which cell populations are selectively removed by GLS1 inhibition in aged mice and to assess how this intervention alters intercellular interactions across different cell types.
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Also filed as BioProject PRJNA1281109 and SRA study SRP593983. Searching any of these in the dataset finder brings you back here.

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