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Immune dysregulation in the prostates of C57BL/6Aire-/- mice mirrors that seen in BPH

GSE300554 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/27 Platform GPL24247
Summary
BPH represents the most prevalent urologic condition affecting aging men and causes considerable morbidity. The pathology is multifaceted, characterized by both stromal and epithelial cell proliferation, tissue fibrosis, lower urinary tract symptoms, and concurrent inflammatory processes. To model human benign prostatic hyperplasia (BPH), we employed 10X Genomics single-cell RNA sequencing to investigate prostate inflammation in C57BL/6 Aire-/- mice.The Aire-deficient mouse model provides a chronic inflammatory environment with intact immune responses, differing only in impaired central immune tolerance. The resulting datasets were subsequently compared against existing human BPH single-cell RNA sequencing data to validate the model's relevance.
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Direct links to NCBI, no account and no request form: the whole study as GSE300554_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1281170 and SRA study SRP593996. Searching any of these in the dataset finder brings you back here.

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