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MRPL37 promotes hepatocellular carcinoma progression through modulating mitochondrial energy metabolism

GSE300565 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/17 Platform GPL34281
Summary
Mitochondrial ribosomal proteins of the large subunit (MRPLs) are critical for mitochondrial protein synthesis and cellular energy metabolism. The role of MRPL37, a member of the MRPL family, in hepatocellular carcinoma (HCC) progression was investigated using SNU-398 HCC cells. In this study, we performed RNA sequencing (RNA-seq) to characterize transcriptomic changes following shRNA-mediated knockdown of MRPL37. The dataset includes RNA profiles from SNU-398 cells with MRPL37 knockdown and corresponding control cells. This analysis aims to elucidate the molecular mechanisms by which MRPL37 regulates mitochondrial function and energy metabolism in HCC. These data provide insights into the role of MRPL37 in HCC progression and may facilitate the identification of novel therapeutic targets for liver cancer.
Published in
MRPL37 promotes hepatocellular carcinoma progression through modulating mitochondrial energy metabolism
Zhang Y, Chen M, Li H et al. · iScience 2025 · PMID 41399509 · doi:10.1016/j.isci.2025.114052
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Also filed as BioProject PRJNA1281387 and SRA study SRP594239. Searching any of these in the dataset finder brings you back here.

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