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Single-cell RNA-seq profiling of treatment-naïve chemo-refractory and chemo-sensitive ovarian cancer

GSE300897 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/03 Platform GPL24676Platform GPL16791Platform GPL20301
Summary
This dataset contains single-cell RNA-seq data from treatment-naïve biopsies of nine patients diagnosed with ovarian high-grade serous carcinoma (HGSC), including four chemo-refractory and five chemo-sensitive cancers. Four of the samples (EOC204, EOC115, EOC649, EOC1127) are newly generated, while five samples have been previously published (GSE165897). The data was generated as part of the DECIDER observational trial (NCT04846933) to investigate the molecular drivers of chemo-refractory HGSC. Key findings from the study indicate that chemo-refractory HGSC is associated with reduced interferon type I (IFN-I) activity and enhanced hypoxia pathway activity, while baseline IFN-I pathway activity in chemo-naïve cancer serves as an independent prognostic factor for chemotherapy response.
Published in
Multi-omics analysis reveals the attenuation of the interferon pathway as a driver of chemo-refractory ovarian cancer
Afenteva D, Yu R, Rajavuori A et al. · Cell reports. Medicine 2025 · PMID 40885189 · doi:10.1016/j.xcrm.2025.102316
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Direct links to NCBI, no account and no request form: the whole study as GSE300897_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1282622. Searching any of these in the dataset finder brings you back here.

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