GEO series
Effect of FL-Fc-DM1 drug on gene expression of Molm-13 cells pretreated with cytarabine.
GSE300904
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2025/06/30
GPL16791
Summary
Cytarabine is one of the first line chemo drugs to treat acute myeloid leukemia (AML). However, cytarabine can induce AML cell cell cycle arrest at G0/G1 phase. These cell-cycle-arrested AML cells resist cytarabine, show a senescence-like phenotype or stem-cell like phenotype. To eliminate these cell-cycle arrested cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the Molm-13 cells as a AML model. The total mRNA of Molm-13 cells treated with different drugs (cytarabine, FL-Fc-DM1) were sequenced.
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Paper (PMID 40975063) ↗
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