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Effect of FL-Fc-DM1 drug on gene expression of THP-1 cells pretreated with cytarabine.

GSE270338 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/06/25 Platform GPL16791
Summary
Cytarabine is one of the first line chemo drugs to treat acute myeloid leukemia (AML). However, cytarabine can induce AML cell cell cycle arrest at G0/G1 phase. These cell-cycle-arrested AML cells resist cytarabine, show a senescence-like phenotype or stem-cell like phenotype. To eliminate these cell-cycle arrested cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the THP-1 cells as a AML model. The total mRNA of THP-1 cells treated with different drugs (cytarabine, FL-Fc-DM1, FL-Fc) were sequenced.
Published in
FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
Zhang D, Guo Y, Peng Z et al. · Cell reports. Medicine 2025 · PMID 40975063 · doi:10.1016/j.xcrm.2025.102365
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Also filed as BioProject PRJNA1126229 and SRA study SRP515033. Searching any of these in the dataset finder brings you back here.

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