GEO series
Simultaneous Targeting of KRAS and CDK4 Synergistically Induces Durable Growth Arrest in Pancreatic Cancer Cells [51T-2D_RNA_Seq]
GSE301146
Homo sapiens
Expression profiling by high throughput sequencing
23 samples
2025/11/12
GPL24676
Summary
We report that the KRAS-G12C inhibitor Sotorasib synergizes with the CDK4/6 inhibitor Palbociclib to eliminate pancreatic ductal adenocarcinoma (PDAC) cells (51T-2D cells) harboring KRAS-G12C mutations. This synergy was especially pronounced following drug washout, indicating a durable cellular response. Mechanistically, the combinations induced sustained cell cycle arrest.
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Paper (PMID 41436723) ↗
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