A ketogenic diet improves memory in females in the APOE4 mouse model of Alzheimer’s disease.
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301153_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1284200 and SRA study SRP596051. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9076408 SD_E51_M_m22_APOE4KI
- GSM9076409 SD_E58_M_m22_APOE4KI
- GSM9076410 SD_E66_M_m22_APOE4KI
- GSM9076411 KD_E53_M_m22_APOE4KI
- GSM9076412 KD_E59_M_m22_APOE4KI
- GSM9076413 KD_E64_M_m22_APOE4KI
- GSM9076414 SD_E62_F_m22_APOE4KI
- GSM9076415 SD_E67_F_m22_APOE4KI
- GSM9076416 KD_E61_F_m22_APOE4KI
- GSM9076417 KD_E68_F_m22_APOE4KI
- GSM9076418 KD_E207_F_m22_APOE4KI
- GSM9076419 SD_E249_F_m22_APOE4KI
- GSM9076420 SD_E265_F_m22_APOE4KI
- GSM9076421 KD_E213_M_m22_APOE4KI
- GSM9076422 SD_E228_F_m22_APOE4KI
- GSM9076423 KD_E256_M_m22_APOE4KI
- GSM9076424 SD_E251_M_m22_APOE4KI
- GSM9076425 KD_E227_F_m22_APOE4KI
- GSM9076426 SD_E264_M_m22_APOE4KI
- GSM9076427 KD_E254_M_m22_APOE4KI
- GSE300079 APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition 10 samples shares apoe4, alzheimer, improves
- GSE262632 Sex-dependent APOE4 Neutrophil-microglia interactions drive cognitive impairment in Alzheimer's Disease 39 samples shares apoe4, alzheimer
- GSE319246 ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer’s Disease via Epigenetic Reprogramming of the AsxL1/LXRα–H3K4me3 Axis 24 samples shares apoe4, alzheimer
- GSE279550 Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis 16 samples shares apoe4, alzheimer
- GSE314221 Reducing CETP activity prevents memory decline in an Alzheimer’s disease mouse model. 16 samples shares alzheimer, memory
- GSE283692 A ketogenic diet and voluntary exercise modify the sciatic nerve and gastrocnemius transcriptome in diet-induced obese mice 96 samples shares ketogenic, diet
- GSE248297 Liver RNA-seq from male C57Bl/6J on a ketogenic diet 15 samples shares ketogenic, diet
- GSE320214 A Ketogenic Diet Sensitizes Pancreatic Cancer to Glutamine Metabolism Inhibitors 10 samples shares ketogenic, diet
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.