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RNA-seq analysis reveals dysregulated pathways in CAFs following NPs treatment.

GSE301220 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/24 Platform GPL24676
Summary
Cancer-associated fibroblasts (CAFs) contribute to immunotherapy resistance in colorectal cancer (CRC) by creating physical barriers and fostering an immunosuppressive microenvironment, critically influencing tumor development and metastasis.Nowadays, nanotherapy has been extensively explored in oncology for its dual capabilities in cancer targeted treatment.However, the mechanisms by which nanoparticles (NPs) exert their antitumor effects through targeting and eliminating CAFs remain incompletely understood.In this study,NPs modulated intrinsic signaling pathways in CAFs, leading to altered chemokine secretion profiles. This modification enhanced dendritic cell maturation and promoted CD8+ T cell activation and functionality, ultimately amplifying the anti-tumor immune response to suppress CRC progression.
Published in
Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy
Wang S, Wang Z, Wu C et al. · Nature communications 2026 · PMID 41690961 · doi:10.1038/s41467-026-69462-5
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Also filed as BioProject PRJNA1280476. Searching any of these in the dataset finder brings you back here.

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