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Developing a T>A Base Editor via Protein Universe Mining and optimizing translesion polymerase

GSE301258 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/08 Platform GPL24676
Summary
A engineering Pol η variants offers the exciting prospect of further tailoring its activity for base editing. Improving its processivity could ensure that Pol η completes the bypass of the AP site and perhaps extends a few more bases before dissociating, thus preventing the recruitment of other, potentially less desirable, cellular polymerases or repair factors. Base on this hypothesis, We decide to develop a novel T-to-A base editor.
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Also filed as BioProject PRJNA1284345 and SRA study SRP596251. Searching any of these in the dataset finder brings you back here.

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