Inhibition of H3K79me2 by DOT1L inhibitor EPZ5676 promotes mouse embryonic lung branching morphogenesis via increasing epithelium proliferation
RNA-seq (gene expression) · mouse · 9 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibition of H3K79me2 by DOT1L Inhibitor EPZ5676 Promotes Mouse Embryonic Lung Branching Morphogenesis via Increasing Epithelium ProliferationFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301374_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1284873 and SRA study SRP596421. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 9 more — browse all 9 samples with per-sample file links →
- GSE279978 In vitro neuronal RNA-sequencing, in vivo cortical single nucleus RNA-sequencing, in vivo cortical ChIP-sequencing of H3K79me2 in models of DOT1L loss 26 samples shares h3k79me2, dot1l
- GSE306634 DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development and germinal center function 21 samples shares h3k79me2, dot1l
- GSE156324 GATA4 regulates epithelial morphogenesis in the developing mouse stomach to promote establishment of a simple columnar epithelium 17 samples shares morphogenesis, epithelium
- GSE282854 Targeting the histone methyltransferase DOT1L rewires CD8 T cells and enhances their intrinsic cytotoxic activity towards tumor cells [RNAseq_WT_KO_DMSO_EPZ] 14 samples shares dot1l
- GSE222233 DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2] 11 samples shares dot1l
- GSE282853 Targeting the histone methyltransferase DOT1L rewires CD8 T cells and enhances their intrinsic cytotoxic activity towards tumor cells [RNAseq_DMSO_SGC] 8 samples shares dot1l
- GSE233974 DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID. [RNA-Seq] 6 samples shares dot1l
- GSE222234 DOT1L controls NK cell maturation and lineage integrity [RNA-seq D5] 6 samples shares dot1l
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.