GEO series
Identification of molecular target of Vindeburnol and its derivatives
GSE301918
Mus musculus
Expression profiling by high throughput sequencing
17 samples
2026/01/21
GPL24247
Summary
Natural products (NPs) often act as sources of CNS-active agents and provide inspiration for the development of synthetic molecules that incorporate their best features. Vindeburnol (VIND; (±)-(3α,14β)-20,21-dinoreburnamenin-14-ol; developmental codes RU24722 or BC19), based on the core structure of eburnamine-vincamine alkaloids, has been extensively investigated for its biological activities. This molecule has demonstrated potential therapeutic properties in various in vivo models of CNS disorders such as multiple sclerosis, Alzheimer’s disease, and depressive-like behavior. Many biochemical experiments which characterize vindeburnol influence on neuromediaters have been studied and published but molecular target in CNS is still unknown. Our research is new attempt to discover it.
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Paper (PMID 41536279) ↗
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