scRNAseq and TCRseq of tumor infiltrating CD8 T cells from samples

The goal of this study is to investigate the role of ageing on tumor infiltrating CD8 T cells Ageing is a major risk factor for various cancers, and patients aged 65 years or older represent up to 60% of newly diagnosed cancer patients. Ageing results in remodeling of T cell immunity, causing poor clinical outcomes in patients with cancer. During ageing, T cells undergo age-dependent changes and gradually lose their physiological function. Numerous studies have revealed that T cells mediate the surveillance and elimination of tumors, and substantial therapeutic strategies have been developed to improve tumor-specific T cell responses. However, these experimental studies were almost exclusively conducted in young but not old individuals. Therefore, how age-associated T cell dysfunction impacts antitumor immunity requires further investigation.