TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype [hASC_RNAseq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × hASC_control_12h vs 3 × hASC_control_72h vs 3 × hASC_TGFb_12h vs 3 × hASC_TGFb_72hGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotypeThe Journal of biological chemistry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302340_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1290108 and SRA study SRP600072. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9102316 hASC_control_12h_1 hASC_control_12h
- GSM9102317 hASC_control_12h_2 hASC_control_12h
- GSM9102318 hASC_control_12h_3 hASC_control_12h
- GSM9102319 hASC_control_72h_1 hASC_control_72h
- GSM9102320 hASC_control_72h_2 hASC_control_72h
- GSM9102321 hASC_control_72h_3 hASC_control_72h
- GSM9102322 hASC_TGFb_12h_1 hASC_TGFb_12h
- GSM9102323 hASC_TGFb_12h_2 hASC_TGFb_12h
- GSM9102324 hASC_TGFb_12h_3 hASC_TGFb_12h
- GSM9102325 hASC_TGFb_72h_1 hASC_TGFb_72h
- GSM9102326 hASC_TGFb_72h_2 hASC_TGFb_72h
- GSM9102327 hASC_TGFb_72h_3 hASC_TGFb_72h
- GSE237690 Lupus dermal fibroblasts hyper-respond to inflammatory cytokines and exhibit a pro-fibrotic phenotype to TGF-β in patients with scarring skin disease 317 samples shares tgf, phenotype
- GSE280810 Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and anti-tumoral activity upon IL-10 or TGFβ stimulation 30 samples shares tgf, phenotype
- GSE293962 STL1267 Inhibits Myofibroblast Differentiation in a TGFβ1-Driven Human Lung Fibroblast Model 16 samples shares tgf, myofibroblast
- GSE221896 Effect of nimodipine on gene expression during TGF-β induced fibrotic phenotype switching of human orbital fibroblasts 11 samples shares tgf, phenotype
- GSE282668 TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration 54 samples shares tgf
- GSE325569 Transcription analysis of primary dermal fibroblasts with different genotypes for CTGF rs9399005 SNP after irradiation or sham irradiation 51 samples shares tgf
- GSE299137 Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma 48 samples shares tgf
- GSE274024 NOX4/NOX1 dual inhibition in cholangiocarcinoma as an effective approach to target TGF-beta protumorigenic actions in cancer associated fibroblasts 45 samples shares tgf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.