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Uncovering the Roles of PPARγ and the Immunoproteasome in ILC2 Regulation

GSE302398 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/11/05 Platform GPL24676
Summary
ILC2 cells were discovered less than 10 years ago. The activation and regulation of these cells have been extensively studied and some mechanisms have been discovered, but certain regulatory pathways have yet to be defined. PPARg and the immunoproteasome seem to play a major role in this regulation, but their exact function is still unknown. The aim of this project is to study the role of both the immunoproteasome and the transcriptional factor PPARg in ILC2 physiology using RNAseq.
Published in
The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity
Laurent P, Chaudhary V, Li D et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 41264257 · doi:10.1073/pnas.2518190122
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Also filed as BioProject PRJNA1290341 and SRA study SRP600175. Searching any of these in the dataset finder brings you back here.

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