GEO series
Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity
GSE302560
Homo sapiens
Expression profiling by high throughput sequencing
144 samples
2026/06/23
GPL24676
Summary
We evaluated the impact of spaceflight on a microphysiologic model of calcium oxalate (CaOx) kidney stone disease. Proximal tubule epithelial cells cultured as confluent microtubules were exposed to CaOx crystals with or without potassium citrate (a potential countermeasure) to determine impact on gene expression. Nine genes were differentially expressed in response to CaOx crystal exposure during spaceflight. This project presents the use of microgravity as a unique environment to study kidney pathophysiology.
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Paper (PMID 40678253) ↗
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