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Transcriptomic profiling of primary mediastinal liposarcoma

GSE302769 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/07/16 Platform GPL24676
Summary
Primary mediastinal liposarcoma (MLPS) is an extremely rare tumor with unclear molecular biology. We conducted RNA sequencing in five cases of MLPS and compared gene expression between dedifferentiated liposarcoma (DDLPS) and well-differentiated liposarcoma (WDLPS). Enrichment analyses and immune cell deconvolution revealed that DDLPS showed features of dedifferentiation, cell cycle activation, Wnt signaling, and immune-cold status. This dataset provides the first transcriptomic landscape of primary MLPS and offers insight into potential therapeutic targets.
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Direct links to NCBI, no account and no request form: the whole study as GSE302769_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1292143. Searching any of these in the dataset finder brings you back here.

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