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FABP4 binding cancer cells exhibit an invasive phenotype via PKC-mitoROS signaling

GSE302775 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/17 Platform GPL24676
Summary
Using several high-fat diet-induced murine obesity models, we demonstrate that obesity promotes breast cancer lung metastasis through elevated levels of adipocyte-derived circulating FABP4. Circulating FABP4 directly binds to a subset of breast cancer cells via the membrane lipid PIP2. This FABP4/PIP2 interaction activates PKC signaling and enhances mitochondrial ROS production, driving cancer cell migration. these findings identify circulating FABP4 as a critical mediator of obesity-driven metastasis and highlight it as a promising therapeutic target for treating metastatic breast cancer.
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Also filed as BioProject PRJNA1292148 and SRA study SRP601226. Searching any of these in the dataset finder brings you back here.

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