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Immunostimulatory CELMoD combination overcomes resistance to T cell engagers caused by high multiple myeloma burden

GSE302797 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/08/01 Platform GPL24247
Summary
Bispecific T cell engagers (TCE) targeting BCMA and CD3 induce deep hematologic responses in approximately 60% of heavily pre-treated multiple myeloma (MM) patients. Pre-treatment with iberdomide and dexamethasone reshaped the bone marrow T cell compartment, promoted infiltration of naïve T cells, and generated 100% response rates and the longest survival in subjects with high tumor burden. This was accompanied by more favorable T cell profiling, with limited expansion of regulatory T cells and exhaustion. In total, administering TCE following dexamethasone and iberdomide treatments provided deeper and more durable responses with reduced risk of CRS. Whole Bone Marrow single cell profiling of immune phenotype of untreated and treated de novo Vk murine model.
Published in
An immunostimulatory CELMoD combination overcomes resistance to T-cell engagers caused by a high multiple myeloma burden
Meermeier EW, Pfeffer K, Stein CK et al. · Blood 2025 · PMID 40864972 · doi:10.1182/blood.2025029215
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Also filed as BioProject PRJNA1292183 and SRA study SRP601287. Searching any of these in the dataset finder brings you back here.

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