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RNA sequencing of flow-sorted lung parenchymal CD226+ and CD226- CD8 T cells from mice chronically infected with Mycobacterium tuberculosis

GSE302813 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/22 Platform GPL21103
Summary
Lung CD8⁺ T cells induced during chronic tuberculosis exhibit functional heterogeneity, comprising both effector and exhausted states. CD226 is the most differentially expressed gene distinguishing effector from exhausted CD8⁺ T cells. Functionally, CD226 serves as a costimulatory molecule that promotes recognition of Mtb-infected macrophages. Loss of CD226 expression correlates with the onset of CD8⁺ T cell exhaustion during tuberculosis.
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Also filed as BioProject PRJNA1292216 and SRA study SRP601355. Searching any of these in the dataset finder brings you back here.

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