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RNA-seq of in vivo B7H3_CAR_T cells loaded with oncolytic virus VSVΔ51

GSE302980 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/28 Platform GPL24676
Summary
To investigate the in vivo functions of CR2/3-CAR-T loaded with VSVΔ51 after infiltrating tumor microenvironment, we analyzed the transcriptomic signatures at early stage after CAR-T infiltrating into tumor tissue. We isolated the CAR-T cells from the mouse tumor and used RNA sequence to study the global gene expression. We identified differentially expressed genes in B7H3-CAR-T cells and CR2/3-B7H3-CAR-T cells loaded with loading VSVΔ51, aiming to identify the changed pathways that are influenced by the cross-connection between VSV-G protein and CR2/3-CAR moiety.
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Direct links to NCBI, no account and no request form: the whole study as GSE302980_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1293198 and SRA study SRP601752. Searching any of these in the dataset finder brings you back here.

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