Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast differentiation by inhibiting Parkin-dependent mitophagy
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast accumulation by inhibiting Parkin-dependent mitophagyNature communications · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303021_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1293366 and SRA study SRP603159. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9115987 C57BL/6 AMs IL‑33 0 h,RNA‑seq (AMs_IL33_0h_1)
- GSM9115988 C57BL/6 AMs IL‑33 3 h,RNA‑seq (AMs_IL33_3h)
- GSM9115989 C57BL/6 AMs IL‑33 6 h,RNA‑seq (AMs_IL33_6h)
- GSM9115990 C57BL/6 AMs IL‑33 12 h,RNA‑seq (AMs_IL33_12h)
- GSM9115991 C57BL/6 AMs IL‑33 24 h,RNA‑seq (AMs_IL33_24h_1)
- GSM9115992 C57BL/6 AMs IL‑33 48 h,RNA‑seq (AMs_IL33_48h)
- GSM9115993 C57BL/6 AMs IL‑33 72 h,RNA‑seq (AMs_IL33_72h)
- GSM9115994 C57BL/6 AMs IL‑33 96 h,RNA‑seq (AMs_IL33_96h)
- GSM9115995 C57BL/6 AMs IL‑33 0 h,RNA‑seq (AMs_IL33_0h_2)
- GSM9115996 C57BL/6 AMs IL‑33 24 h,RNA‑seq (AMs_IL33_24h_2)
- GSM9115997 C57BL/6 AMs IL‑33 0 h,RNA‑seq (AMs_IL33_0h_3)
- GSM9115998 C57BL/6 AMs IL‑33 24 h,RNA‑seq (AMs_IL33_24h_3)
- GSM9115999 C57BL/6 Fibroblast TGF‑β1 24 h,RNA‑seq (Fib_TGFβ1_24h)
- GSE280007 EZH2-mediated macrophage-to-myofibroblast transition contributes to calcium oxalate crystal-induced kidney fibrosis 6 samples shares myofibroblast, macrophage
- GSE301845 Tenascin C+ myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions 1 samples shares myofibroblast, macrophage
- GSE83337 Genetic lineage tracing defines myofibroblast origin and function in the injured heart 185 samples shares myofibroblast
- GSE169703 Prrx1 is a Master Transcription Factor of myofibroblastic Cancer-Associated Fibroblasts [Murine_Fibroblast_RNA_seq] 21 samples shares myofibroblast
- GSE302341 TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype [10T_RNAseq] 18 samples shares myofibroblast
- GSE261166 Transcription factor 21 regulates cardiac myofibroblast formation and fibrosis [RNA-Seq] 16 samples shares myofibroblast
- GSE273713 Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis 12 samples shares myofibroblast
- GSE248726 Single-cell RNA-seq of alveolar myofibroblasts and other clusters 10 samples shares myofibroblast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.