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Brain-infiltrating ILC2s-derived alpha-calcitonin gene-related peptide promoting angiogenic sprouting accelerates post-stroke angiogenesis

GSE303092 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/23 Platform GPL24247
Summary
Group 2 innate lymphoid cells (ILC2s) are key players in immune regulation and tissue repair in barrier immunity, but they are rarely seen in the brain. Since ILC2s can be intrinsically expanded by IL2/IL2 antibody complex, we investigated the transcriptomic changes induced by IL2/IL2 antibody complex (IL2-JES6-1) after ischemic stroke, we performed single-cell RNA sequencing of the CD45high immune cells from the infarcted hemisphere at day 14 after MCAO using 10x Genomics scRNAseq. To investigate the key mechanism of ILC2s-mediated long-term recovery after ischemic stroke, we performed single-cell RNA sequencing of the infarcted hemisphere at day 14 after MCAO using 10x Genomics scRNAseq.
Published in
Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production
Ping A, Yang F, Lu L et al. · The Journal of experimental medicine 2025 · PMID 40853291 · doi:10.1084/jem.20241830
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Also filed as BioProject PRJNA1294141 and SRA study SRP602342. Searching any of these in the dataset finder brings you back here.

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