Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KPTC CUT&RUN]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 ComplexesCancer discovery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303178_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1294294 and SRA study SRP602400. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 5 replicated groups read from 12 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9119872 KPTC_IgG_rep1 KPTC_IgG
- GSM9119873 KPTC_H3K4me3_rep1 KPTC_H3K4me3
- GSM9119874 KPTC_H3K14ac_rep1 KPTC_H3K14ac
- GSM9119875 KPTC_H3K14ac_rep2 KPTC_H3K14ac
- GSM9119876 KPTC_KMT2A_rep1 KPTC_KMT2A
- GSM9119877 KPTC_KMT2A_rep2 KPTC_KMT2A
- GSM9119878 KPTC_KAT7_rep1 KPTC_KAT7
- GSM9119879 KPTC_KAT7_rep2 KPTC_KAT7
- GSM9119880 KPTC_IgG_rep2 KPTC_IgG
- GSM9119881 KPTC_CTCF
- GSM9119882 KPTC_H3K4me3_rep2 KPTC_H3K4me3
- GSM9119883 KPTC_H3K4me3_rep3 KPTC_H3K4me3
- GSE303264 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KP787] 11 samples shares hbo1, mll1, coordinated, suppression, epigenomic
- GSE282851 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [scRNA-seq] 10 samples shares hbo1, mll1, coordinated, suppression, epigenomic
- GSE300328 Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs [CUT&RUN] 12 samples shares cut, run, epigenomic
- GSE289642 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [ChIP-Seq, Cut & Run] 107 samples shares cut, run
- GSE303384 Mechanism of maintenance and establishment of repression by the Mtg16 tumor suppressor [CUT&RUN, ChIP-Seq] 92 samples shares cut, run
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples shares cut, run
- GSE313359 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [Cut & Run] 45 samples shares cut, run
- GSE292333 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes [CATCH-seq and CUT&RUN] 44 samples shares cut, run
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.