GEO series
eIF4E2 Deficiency Drive Cisplatin Resistance in NSCLC
GSE303283
Homo sapiens
Expression profiling by high throughput sequencing; Other
16 samples
2026/03/24
GPL24676
Summary
Cisplatin resistance remains a major obstacle in treating non-small cell lung cancer (NSCLC). Mechanistic insights into the translational control of cisplatin resistance remain sparse. This study identifies eIF4E2 as a critical translational regulator whose downregulation elevates DNA repair capacity and drives cisplatin resistance.
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