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Single-cell Transcriptomic Profile of Brain Immune Cells From Alzheimer’s Disease Mouse Models With or Without CD8+ T Cell–Specific Nr4a Deletion

GSE303309 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2025/09/05 Platform GPL24247
Summary
We performed single-cell RNA sequencing (scRNA-seq) and T cell receptor sequencing (scTCR-seq) using the 10x Genomics platform to characterize brain-infiltrating CD8+ T cells and their interactions with brain immune cells in the App^NL-G-F Alzheimer’s disease mouse model, with or without CD8⁺ T cell–specific deletion of Nr4a. This dataset provides comprehensive transcriptional profiles of brain immune cells and insights into CD8+ T cell clonal expansion in the context of amyloid pathology.
Published in
Stage-specific roles of clonally expanded CD8(+) T cells in regulating amyloid pathology in Alzheimer's disease models
Ohyagi M, Ito M, Iizuka-Koga M et al. · Nature communications 2025 · PMID 41145447 · doi:10.1038/s41467-025-64503-x
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Direct links to NCBI, no account and no request form: the whole study as GSE303309_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1294811 and SRA study SRP602738. Searching any of these in the dataset finder brings you back here.

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