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Hells protects mitochondrial integrity via Nr2f2 suppression during osteoclast differentiation

GSE303340 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/01 Platform GPL24247
Summary
Osteoclasts are bone-resorbing cells essential for skeletal remodeling. The chromatin remodeler Hells has been implicated in epigenetic regulation during cellular differentiation, but its role in osteoclastogenesis remains unclear. To investigate the function of Hells in osteoclast differentiation, we performed RNA sequencing of bone marrow-derived macrophages (BMMs) treated with RANKL, with or without siRNA-mediated knockdown of Hells. This dataset provides transcriptomic profiles of Hells-deficient and control osteoclast precursors, offering insight into the epigenetic control of osteoclastogenesis.
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Direct links to NCBI, no account and no request form: the whole study as GSE303340_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1294872 and SRA study SRP602740. Searching any of these in the dataset finder brings you back here.

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