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Esophageal progenitor cell plasticity; a 3D organotypic model of epithelial regeneration [scATAC-seq]

GSE303427 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/10/02 Platform GPL34328
Summary
Epithelial stem cells are capable of remarkable plasticity, facilitating efficient regenerative responses following damage. Here, we present a versatile model of ectopic niche regeneration that provides evidence of a switch in epithelial stem cell identity as a response to foreign microenvironmental signals. A combination of 3D organotypic cultures, 3D confocal imaging and Next-Generation Sequencing reveal events of epithelial plasticity during the reepithelialization of denuded stroma. In this study we provide new insights on the mechanisms driving cell fate flexibility in adult epithelial stem cells.
Published in
Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion
Bejar MT, Jimenez-Gomez P, Moutsopoulos I et al. · Nature communications 2025 · PMID 41309646 · doi:10.1038/s41467-025-66446-9
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Also filed as BioProject PRJNA1295391 and SRA study SRP602941. Searching any of these in the dataset finder brings you back here.

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