SnRNAseq of tumors isolated from Apc cKO; Kras-mutant animals
Single-nucleus RNA-seq · mouse · 12 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Apc_KO_Kras_G12D vs 4 × Apc_KO_Kras_Q61R vs 4 × Apc_KO_Kras_WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303719_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1297153 and SRA study SRP603789. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9134566 Apc_KO_Kras_G12D_rep1 Apc_KO_Kras_G12D
- GSM9134567 Apc_KO_Kras_G12D_rep2 Apc_KO_Kras_G12D
- GSM9134568 Apc_KO_Kras_G12D_rep3 Apc_KO_Kras_G12D
- GSM9134569 Apc_KO_Kras_G12D_rep4 Apc_KO_Kras_G12D
- GSM9134570 Apc_KO_Kras_Q61R_rep2 Apc_KO_Kras_Q61R
- GSM9134571 Apc_KO_Kras_Q61R_rep3 Apc_KO_Kras_Q61R
- GSM9134572 Apc_KO_Kras_Q61R_rep4 Apc_KO_Kras_Q61R
- GSM9134573 Apc_KO_Kras_Q61R_rep5 Apc_KO_Kras_Q61R
- GSM9134574 Apc_KO_Kras_WT_rep1 Apc_KO_Kras_WT
- GSM9134575 Apc_KO_Kras_WT_rep2 Apc_KO_Kras_WT
- GSM9134576 Apc_KO_Kras_WT_rep3 Apc_KO_Kras_WT
- GSM9134577 Apc_KO_Kras_WT_rep4 Apc_KO_Kras_WT
- GSE301967 Multiome analysis of tumors isolated from Apc cKO; Kras-mutant animals 12 samples shares kras-mutant, isolated, animals
- GSE327960 Transcription profiles of mouse microglia isolated by FACS from WT and Grn KO animals, separated by lipofuscin levels [hex001110] 24 samples shares isolated, animals
- GSE155577 Gene expression data from epithelial and mesenchymal tumor cells isolated from E-A14 mouse mammary tumors grown in immunodeficient and immunocompetent mice 26 samples shares isolated
- GSE236258 Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation 15 samples shares kras-mutant
- GSE279330 Tumor CD45+ cells and spleen LY6G+ PMNs isolated from Hdc-GFP mice with subcutaneous ACKP syngeneic GC line-established tumors and treated with TFF2-MSA and/or anti-PD-1 therapies. 8 samples shares isolated
- GSE115706 RNAseq of motor neurons and neurons with differential vulnerability isolated from a mouse model of spinal muscular atrophy using laser capture microdissection 168 samples shares isolated
- GSE309637 Effects of TCDD on gene expression in hepatocytes isolated from WT and PkmΔDRE mice. 144 samples shares isolated
- GSE271744 Bulk RNAseq of mononucleated cells isolated from resting and regenerating adult and aged skeletal mouse muscle 107 samples shares isolated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.