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Tumor CD45+ cells and spleen LY6G+ PMNs isolated from Hdc-GFP mice with subcutaneous ACKP syngeneic GC line-established tumors and treated with TFF2-MSA and/or anti-PD-1 therapies.

GSE279330 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/23 Platform GPL24247
Summary
We designed a novel TFF2-MSA peptide as a CXCR4 partial agonist, and used it either alone or in combination with anti-PD-1 to treat established ACKP tumors. PMNs are known to be highly heterogenous, thus these tumors are grown in Hdc-GFP host mice to trace Hdc+ PMN subsets. We then used single cell-RNA sequencing (scRNA-seq) to elucidate the effect of TFF2-MSA on tumor and spleen PMNs, and more broadly the tumor microenvironment.
Published in
A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis
Qian J, Ma C, Waterbury QT et al. · Cancer cell 2025 · PMID 40578360 · doi:10.1016/j.ccell.2025.06.006
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Also filed as BioProject PRJNA1171867 and SRA study SRP538006. Searching any of these in the dataset finder brings you back here.

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