← BioTransfer GEO Dataset Finder
GEO series

RNA-Seq of Mouse Embryonic Heart Development in Atf4 Exon 3 Frameshift Knockout Mice

GSE303780 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/18 Platform GPL24247
Summary
This dataset contains RNA sequencing (RNA-seq) profiles from embryonic hearts of Atf4 del7/del7 mice, which harbor a 7-base-pair deletion in exon 3 of Atf4 resulting in complete loss of ATF4 protein expression. The purpose of this experiment is to evaluate the transcriptional consequences of ATF4 deficiency in embryonic cardiomyocytes, independent of transcriptional readthrough artifacts associated with an earlier widely used Atf4 floxed mouse model. RNA-seq was performed on ventricular tissue collected from E11.5 embryos of Atf4 del7/del7 mice and their wild-type littermates to assess gene expression changes associated with loss of ATF4 protein.
Published in
Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart development
Zhang Z, Wu T, Chen Z et al. · Cardiovascular research 2026 · PMID 41248983 · doi:10.1093/cvr/cvaf237
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE303780_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1297674 and SRA study SRP603974. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.