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Human iPSC-Derived Spinal Neural Progenitors Enhance Sensorimotor Recovery in Spinal Cord-Injured NOD-SCID Mice via Differentiation and Microenvironment Regulation

GSE303787 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/05 Platform GPL24676Platform GPL34284
Summary
We developed a therapeutic approach by transplanting spinal neural progenitor cells (spNPGs), derived from human induced pluripotent stem cell (iPSC)-generated neuromesodermal progenitors, into a contusive spinal cord injury (SCI) model in NOD-SCID mice. Single-cell RNA sequencing mapped the in vitro differentiation of iPSC-spNPGs, confirming their specification into spinal neuronal lineages. Single-nucleus transcriptomics at one-week post-transplantation showed that the grafted cells differentiated in vivo into motor neurons and two interneuron subtypes (V2 and dI4).
Published in
Human iPSC-derived spinal neural progenitors enhance sensorimotor recovery in spinal cord-injured NOD-SCID mice via differentiation and microenvironment regulation
Yao X, Zhang K, Na T et al. · Cell death & disease 2025 · PMID 40846836 · doi:10.1038/s41419-025-07961-x
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Also filed as BioProject PRJNA1297406 and SRA study SRP603864. Searching any of these in the dataset finder brings you back here.

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