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snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis

GSE303810 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/07/09 Platform GPL24676
Summary
Autoantibodies (ABs) against intracellular proteins, including glutamate-decarboxylase 65 (anti-GAD65), are increasingly recognized in autoimmune and limbic encephalitis (AE/LE). Anti-GAD65 LE frequently progresses into severe temporal lobe epilepsy (TLE), neuropathologically characterized by hippocampal sclerosis (HS) and variable cytotoxic T lymphocytes (CTLs) infiltration. Recently, we have identified Drebrin as a novel intracellular target protein of ABs in patients suspicious for AE. Here, we report on the hippocampal neuropathological sequelae and single-nuclei RNA sequencing (snRNA-seq) of anti-Drebrin- versus anti-GAD65-positive TLE patients, in concert with key clinical parameters from a large patient cohort.
Published in
Forkhead box versus NF-κB hippocampal snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis
van Loo KMJ, Galvis-Montes DS, Breuer A et al. · Journal of neuroinflammation 2026 · PMID 42415095 · doi:10.1186/s12974-026-03951-8
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Also filed as BioProject PRJNA1297713 and SRA study SRP604014. Searching any of these in the dataset finder brings you back here.

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