GEO series
P2X7-mediated mitochondrial calcium overload induces CD8+ T cell senescence
GSE303869
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
9 samples
2026/07/29
GPL34328
Summary
Neutral lipid levels (Bodipy 493/503) were increased in aged CD8⁺ T cells. We thus selectively removed the lipid sensing transcription factor Rxra and Rxrb in T-lineage cells (Cd4-Cre⁺/⁻ Rxra^f/f Rxrb^f/f; hereafter TDKO). Preliminary phenotyping confirmed that TDKO mice harbour a higher frequency of senescent (fSA-βGal⁺) CD8⁺ T cells relative to wild-type (WT) controls, prompting a comparative survey.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse ChIP / ATAC / CUT&Tag datasets →
Similar datasets
- GSE339012 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [ChIP-Seq] 22 samples
- GSE249984 Androgen receptor action in mouse granulosa cells in response to LH surge 14 samples
- GSE324864 HP1B and H3K9me3 Regulate Olfactory Receptor Choice and 2 Transcriptional Identity [ChIP-seq] 28 samples
- GSE328495 Gene expression + ATAC profiling of trisomic hippocampal neurons upon SAHA treatment [ATAC-seq] 16 samples
- GSE292285 Depletion of lamin-associated polypeptide 2 alpha leads to chromatin reorganization and redistribution of A-type lamins to open genomic regions [ChIP-seq] 22 samples
- GSE306458 ACVR1-mediated glycolytic reprogramming promotes histone lactylation and neuronal pyroptosis in neuropathic pain {ChIP-seq] 12 samples
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples
- GSE324933 DGCR8 promotes RNA polymerase II pause release independently of DROSHA [ChIP-seq] 32 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.