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RNA sequencing analysis of photon irradiated 5-, 7- and 11-day old thyroid gland organoids

GSE303892 Mus musculus (mouse) RNA-seq (gene expression) 27 samples Submitted 2026/07/01 Platform GPL19057
At a glance

RNA-seq (gene expression) · mouse · 27 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
27 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF-β modulationCell death & disease · 2026
Summary (written by the submitters)
The specific effects of radiotherapy treatment on thyroid physiology remain poorly understood. In our previous work, we characterized thyroid gland organoids grown from isolated mice thyroid cells. Herein, we used this model to investigate the events occurring at 2 days post-irradiation (corresponding to 7-day-old organoids) and at 6 days post-irradiation (corresponding to 11-day-old organoids) using bulk RNA sequencing.
Read the full summary ↓
To compare the expression profile to an healthy standard sample, 5-day-old organoids (day of irradiation) were used as controls. This analysis outlined key dysregulated pathways activated in thyroid cells with photon exposure.
Published in
Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF-β modulation
Maturi R, Soto-Gamez A, Jellema-de Bruin AL et al. · Cell death & disease 2026 · PMID 42380097 · doi:10.1038/s41419-026-09048-7
This dataset
Open GSE303892 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303892_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1298175 and SRA study SRP604317. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42380097) ↗
Study design
9 conditions, mostly in triplicate
Control, organoids, 5 days, mouse ×3 Control, organoids, 7 days, mouse ×3 2 Gy Irradiated, organoids, 7 days, mouse ×3 4 Gy Irradiated, organoids, 7 days, mouse ×3 7 Gy Irradiated, organoids, 7 days, mouse ×3 Control, organoids, 11 days, mouse ×3 2 Gy Irradiated, organoids, 11 days, mouse ×3 4 Gy Irradiated, organoids, 11 days, mouse ×3 +1 more

Supports a between-group comparison across 27 samples.

How we read this: 9 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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